Five-year, $3.6 million federal grant to fuel search for biomarker-based methods to evaluate suicide risk
In the first study of its kind, scientists from Pine Rest, Van Andel Institute, and Columbia University will seek to identify blood-based biomarkers for suicide risk, laying the foundation for a test that could allow for earlier, life-saving intervention. Enrollment for the five-year study is slated to begin enrolling at Pine Rest in October.
Lead Investigators are:
- Eric Achtyes, M.D., M.S., Pine Rest Christian Mental Health Services
- Lena Brundin, M.D., Ph.D., Van Andel Institute
- John Mann, M.D., Columbia University Department of Psychiatry
Research at Pine Rest
Research offers the opportunity for our staff and patients to be involved in novel and innovative approaches to psychiatric care. By partnering with the biotechnology community, industry and academia-based research programs, Pine Rest demonstrates its dedication to advancing the diagnosis and treatment of psychiatric disorders.
The Pine Rest clinican staff and MSU College of Human Medicine faculty members have been published in several high impact scientific journals on depression, schizophrenia, dementia, bipolar disorder, bioethics, epidemiology, inflammation, smoking cessation, selective serotonin reuptake inhibitors (SSRIs) and platelet function, and have worked on projects involving pharmacogenomics, electroconvulsive therapy, new depression screening tools and psychotropic medications, biomarkers of depression, and the impact of forgiveness and spirituality on treatment outcomes. Clinical staff and faculty members also serve as reviewers for numerous peer-reviewed journals as well as members of institutional review boards and NIH study sections.
Some of our recent research collaborations have included partnerships with Duke University, Fuller Theological Seminary, Mayo Clinic, McLean Hospital (Harvard Medical School Affiliate), Michigan State University, National Institutes of Health, University of Chicago, University of Michigan, University of Pittsburgh, Van Andel Research Institute and Washington University Saint Louis.
Other Research Studies
A Randomized Controlled Trial of Electroconvulsive Therapy versus Usual Care for the Acute Management of Severe Agitation in Alzheimer’s Dementia (ECT-AD)
National Institute on Aging (NIA) and Michigan State University College of Human Medicine
About the Project
Collaboration with McLean Hospital (Harvard Medical School Affiliate, Belmont, Massachusetts), Emory University (Atlanta, Georgia), Mayo Clinic (Rochester, Minnesota), Northwell Health (Manhattan, New York City, New York) and The Medical University of South Carolina (Charleston, South Carolina).
VOCATIONS addendum study: Correlating Depression Symptoms and Suicidality to Inflammatory Biomarkers of Depression
Collaboration with Van Andel Research Institute (Grand Rapids, Michigan)
An Inflammatory Profile Linked to Increased Suicide Risk
Collaboration with Michigan State University, University of Chicago, University of Maryland-Baltimore School of Medicine, University of Texas Southwestern and Van Andel Research Institute.
Safety and Utility of Electroconvulsive Therapy for Agitation and Aggression in Dementia
Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE study)
Collaboration with Cherry Health (Grand Rapids, Michigan)
- The RAISE early treatment program for first-episode psychosis: background, rationale, and study design.
- Cardiometabolic risk in patients with first-episode schizophrenia spectrum disorders: baseline results from the RAISE-ETP study.
- Comprehensive Versus Usual Community Care for First-Episode Psychosis: 2-Year Outcomes From the NIMH RAISE Early Treatment Program.
- Cost-Effectiveness of Comprehensive, Integrated Care for First Episode Psychosis in the NIMH RAISE Early Treatment Program.
Highlights from the 2017 Depression Summit were featured on this episode of WZZM’s “The Exchange.”
2019 Depression Summit for Researchers and Clinicians
On April 26, 2019, Pine Rest and the Michigan State University College of Human Medicine (MSU) hosted their second Depression Summit in Grand Rapids, Michigan, to draw attention to the problem of depression and stimulate research. Together with MSU, Pine Rest is an associate member of the National Network of Depression Centers.
- John Greden, MD, University of Michigan
- Lawrence Park, MD, National Institute of Health / National Institute of Mental Health
- Peter Zandi, PhD, Johns Hopkins University
- Viviane Labrie, PhD, Van Andel Institute
- Kara Zivin, PhD, University of Michigan
- Eric Achtyes, MD, Pine Rest Christian Mental Health Services
SAVE THE DATE! The 2020 Depression Summit is scheduled for October 14, 2020.
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Five-year, $3.6 million federal grant to fuel search for biomarker-based methods to evaluate suicide risk. The project is the first longitudinal study of its kind, and is a collaboration between Van Andel Institute’s Lena Brundin, M.D., Ph.D., Pine Rest Christian Mental Health Services’ Eric Achtyes, M.D., M.S., and Columbia University Department of Psychiatry’s John Mann, M.D.
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