Five-year, $3.6 million federal grant to fuel search for biomarker-based methods to evaluate suicide risk
In the first study of its kind, scientists from Pine Rest, Van Andel Institute, and Columbia University will seek to identify blood-based biomarkers for suicide risk, laying the foundation for a test that could allow for earlier, life-saving intervention. Enrollment for the five-year study is slated to begin enrolling at Pine Rest in October.
Lead Investigators are:
- Eric Achtyes, M.D., M.S., Pine Rest Christian Mental Health Services
- Lena Brundin, M.D., Ph.D., Van Andel Institute
- John Mann, M.D., Columbia University Department of Psychiatry
Research at Pine Rest
Research offers the opportunity for our staff and patients to be involved in novel and innovative approaches to psychiatric care. By partnering with the biotechnology community, industry and academia-based research programs, Pine Rest demonstrates its dedication to advancing the diagnosis and treatment of psychiatric disorders.
The Pine Rest clinican staff and MSU College of Human Medicine faculty members have been published in several high impact scientific journals on depression, schizophrenia, dementia, bipolar disorder, bioethics, epidemiology, inflammation, smoking cessation, selective serotonin reuptake inhibitors (SSRIs) and platelet function, and have worked on projects involving pharmacogenomics, electroconvulsive therapy, new depression screening tools and psychotropic medications, biomarkers of depression, and the impact of forgiveness and spirituality on treatment outcomes. Clinical staff and faculty members also serve as reviewers for numerous peer-reviewed journals as well as members of institutional review boards and NIH study sections.
Some of our recent research collaborations have included partnerships with Duke University, Fuller Theological Seminary, Mayo Clinic, McLean Hospital (Harvard Medical School Affiliate), Michigan State University, National Institutes of Health, University of Chicago, University of Michigan, University of Pittsburgh, Van Andel Research Institute and Washington University Saint Louis.
Pine Rest Research Studies
A Randomized Controlled Trial of Electroconvulsive Therapy versus Usual Care for the Acute Management of Severe Agitation in Alzheimer’s Dementia (ECT-AD)
National Institute on Aging (NIA).
About the Project
Collaboration with McLean Hospital (Harvard Medical School Affiliate, Belmont, Massachusetts), Emory University (Atlanta, Georgia), Mayo Clinic (Rochester, Minnesota), Northwell Health (Manhattan, New York City, New York) and The Medical University of South Carolina (Charleston, South Carolina).
VOCATIONS study: Validation of Computer Adaptive Testing for Mental Health (CAT-MH) in an Outpatient Setting
VOCATIONS addendum study: Correlating Depression Symptoms and Suicidality to Inflammatory Biomarkers of Depression
Collaboration with Van Andel Research Institute (Grand Rapids, Michigan)
- An inflammatory profile linked to increased suicide risk. (Collaboration with Michigan State University, University of Chicago, University of Maryland-Baltimore School of Medicine, University of Texas Southwestern and Van Andel Research Institute.)
- The acute-phase mediator serum amyloid A is associated with symptoms of depression and fatigue.
Safety and Utility of Electroconvulsive Therapy for Agitation and Aggression in Dementia
- Safety and utility of acute electroconvulsive therapy for agitation and aggression in dementia.
- Study of Electroconvulsive Therapy (ECT) Treatment for Agitation and Aggression in Dementia
Forgiveness and Spiritual Distress in an Inpatient Psychiatric Setting
Collaboration with Fuller Theological Seminary (Pasadena, California)
- God imagery and affective outcomes in a spiritually integrative inpatient program.
- Patient patients: Increased patience associated with decreased depressive symptoms in psychiatric treatment
- Spiritual struggles and mental health outcomes in a spiritually integrated inpatient program
- Understanding the roles of religious comfort and strain on depressive symptoms in an inpatient psychiatric setting.
Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE study)
Collaboration with Cherry Health (Grand Rapids, Michigan)
- The RAISE early treatment program for first-episode psychosis: background, rationale, and study design.
- An Integrated Program for the Treatment of First Episode of Psychosis (RAISE ETP)
- Cardiometabolic risk in patients with first-episode schizophrenia spectrum disorders: baseline results from the RAISE-ETP study.
- Comprehensive Versus Usual Community Care for First-Episode Psychosis: 2-Year Outcomes From the NIMH RAISE Early Treatment Program.
- Cost-Effectiveness of Comprehensive, Integrated Care for First Episode Psychosis in the NIMH RAISE Early Treatment Program.
- Longitudinal associations of family burden and patient quality of life in the context of first-episode schizophrenia in the RAISE-ETP study
The Biological Triggers of Depression in Pregnancy (Kynurenine Pathway Metabolites in Perinatal Depression and Suicidality)
- Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression.
Effects of Successful Treatment of Perinatal Mood and Anxiety Disorders on Copper and Zinc Levels.
Funded by Pine Rest Foundation Wondergem grant.
Long Term Antipsychotic Pediatric Safety Trial.
Collaboration with: Duke University.
Genetics of Electroconvulsive Therapy (ECT).
Funded by: National Institute of Mental Health (NIMH).
Collaboration with: National Network of Depression Centers (NNDC).
- International Consortium on the Genetics of Electroconvulsive Therapy and Severe DepressiveDisorders (Gen-ECT-ic).
Highlights from the 2017 Depression Summit were featured on this episode of WZZM’s “The Exchange.”
2019 Depression Summit for Researchers and Clinicians
On April 26, 2019, Pine Rest and the Michigan State University College of Human Medicine (MSU) hosted their second Depression Summit in Grand Rapids, Michigan, to draw attention to the problem of depression and stimulate research. Together with MSU, Pine Rest is an associate member of the National Network of Depression Centers.
- John Greden, MD, University of Michigan
- Lawrence Park, MD, National Institute of Health / National Institute of Mental Health
- Peter Zandi, PhD, Johns Hopkins University
- Viviane Labrie, PhD, Van Andel Institute
- Kara Zivin, PhD, University of Michigan
- Eric Achtyes, MD, Pine Rest Christian Mental Health Services
SAVE THE DATE! The 2020 Depression Summit is scheduled for October 14, 2020.
Study aims to identify genetic variation that contributes to risk of major depressive disorder and response to electroconvulsive therapy Pine Rest Christian Mental Health Services is participating in a National Institute of Mental Health (NIMH) study related to major depressive…
A runaway, inflammatory immune response may be responsible for triggering severe depression during and after pregnancy, according to a new study published in the journal Brain, Behavior and Immunity. Not to be mistaken for the rapidly passing “baby blues,” which…
Five-year, $3.6 million federal grant to fuel search for biomarker-based methods to evaluate suicide risk. The project is the first longitudinal study of its kind, and is a collaboration between Van Andel Institute’s Lena Brundin, M.D., Ph.D., Pine Rest Christian Mental Health Services’ Eric Achtyes, M.D., M.S., and Columbia University Department of Psychiatry’s John Mann, M.D.
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